A Bayesian approach for applying Haseman-Elston methods
نویسندگان
چکیده
منابع مشابه
Relationship between LD Score and Haseman-Elston Regression
Estimating SNP-heritability from summary statistics using LD Score regression provides a convenient alternative to standard variance component models, because LD Score regression is computationally very fast and does not require individual genotype data. However, the mathematical relationship between variance component methods and LD Score regression is not clear; in particular, it is not known...
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Forty years ago, Steven G. Vandenberg and I founded Behavior Genetics (Vandenberg and DeFries 1970). Because one of the most frequently cited articles in human genetics (Haseman and Elston 1972) was published in the first issue of Volume 2 of this journal, its current Executive Editor, John K. Hewitt, agreed that this might be an appropriate time to share my recollections regarding the publicat...
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A common practice among researchers performing linkage studies is the use of equal allele frequencies as input when reporting p-values from computer linkage programs such as S.A.G.E. SIBPAL. Our results, using 5,000 sets from a uniform-prior distribution of allele frequencies, showed that such input may be problematic. Further, we found that the S.A.G.E. SIBPAL test for proportion of alleles sh...
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OBJECTIVE One of the first tools for performing linkage analysis, Haseman-Elston regression (HE), has been successfully used to identify linkages to several disease traits. A recent explosion in extensions of HE leaves one faced with the task of choosing a flavor of HE best suited for a given situation. This paper puts this dilemma into perspective and proposes a modification to HE for highly a...
متن کاملQuantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression.
Two of the major approaches for linkage analysis with quantitative traits in humans include variance components and Haseman-Elston regression. Previously, these were viewed as quite separate methods. We describe a general model, fit by use of generalized estimating equations (GEE), for which the variance components and Haseman-Elston methods (including many of the extensions to the original Has...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2005
ISSN: 1471-2156
DOI: 10.1186/1471-2156-6-s1-s39